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Prisco's Week 2 NFL picks: Bills beat Lions in shootout; Chargers, Patriots, Cowboys bounce back

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By Nexvoro Tech Wire
PUBLISHED THU, SEP 17, 2026 6:38 AM UTC6 MIN READ

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Prisco's Week 2 NFL picks: Bills beat Lions in shootout; Chargers, Patriots, Cowboys bounce back
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Primary Journalistic Dispatch & Direct Reporting

Like I said last week, Week 1 can be a challenge, so I will take my 12-4 straight-up record last week and my 9-7 mark against the spread.

Normally Week 2 is get-even week, a chance for bad teams to play better and for good teams to show maybe they weren't as good as we thought. I took that somewhat into account making these picks.

Get-even week doesn't always work, but I like the theory.

In-Depth Developments & Factual Context

For example, the Chargers will beat the Raiders and cover this week after a terrible showing in losing to the Cardinals at home last week. Several other teams that lost last week will get right as well.

This will be a treat to watch. Both offenses can roll up big numbers and the defenses have issues. But playing on the road on a short week is always a challenge and it will be for the Lions . Look for Josh Allen to win a shootout with Jared Goff and the Lions' offense. Enjoy the fireworks.

The Panthers were mauled on defense last week by the Bears . This Falcons offense isn't close to that. But I think they will just hand it to Bijan Robinson to keep the Panthers off the field. Falcons win it behind Robinson's big day.

Industry Impact & Strategic Analysis

This will be Carson Wentz at quarterback for the Vikings . But the marquee matchup is the Brian Flores defense against the explosive Bears offense. At home, look for the Chicago offense to keep it rolling. Bears take it.

The Titans were bad in losing to the Jets last week, while Philadelphia did some good things in its victory over the Commanders . I think that will carry over as the Eagles ' defense plays better in this one. Eagles roll as the offense also puts up some nice numbers.

New England has been off for a while since losing the opener to the Seahawks . The offense was bad that night. It will be better here. The Steelers didn't do much on offense in the victory over the Falcons, which I think will carry over in this one. This is a low-scoring game with the Pats winning it.

Forward Outlook & Market Perspective

The Packers are playing consecutive road games and blew a double-digit lead against the Vikings in Week 1. So they have to be focused here. The Jets looked good in beating the Titans, but this is a big step up in competition. Look for the Packers to bounce back.

The Browns are back in Florida after their horrible showing in Week 1 in Jacksonville. The Bucs lost to the Bengals on the road but the defense played well. Look for Baker Mayfield to bounce back after a turnover-plagued game. Bucs big.

The Saints are out on the road for a second-consecutive week. That's tough for a young team. It's even tougher facing this Ravens offense. Lamar Jackson looked great last week and has the feel of another potential MVP. There are injuries at receiver, but I think they can work around that here.

This is one of the best games of the weekend. The marquee matchup is Joe Burrow and the passing game against the Texans ' defense. That defense was shredded by Josh Allen last week. The unit will bounce back and play better here, while C.J. Stroud does enough on offense to win it.

The Jaguars are riding high after blowing out Cleveland, while the Broncos are coming off a bad loss to the Chiefs on Monday night. The Jaguars went to Denver and beat them last December and I think they will beat them again. Look for a big game from Bhayshul Tuten running it for Jacksonville.

The Chargers are almost in a must-win situation with the schedule they face in the next six weeks. The loss last week at home to the Cardinals was embarrassing. The Raiders beat the Dolphins , but this is a big step up for them. I see the Chargers bouncing back and the offense actually showing some life.

Reporting synthesized and verified under Nexvoro.tech editorial guidelines. Full primary records referenced via CBS Sports.

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